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34 results

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Common and rare variants in SCN10A modulate the risk of atrial fibrillation.
Jabbari J, Olesen MS, Yuan L, Nielsen JB, Liang B, Macri V, Christophersen IE, Nielsen N, Sajadieh A, Ellinor PT, Grunnet M, Haunsø S, Holst AG, Svendsen JH, Jespersen T. Jabbari J, et al. Circ Cardiovasc Genet. 2015 Feb;8(1):64-73. doi: 10.1161/HCG.0000000000000022. Circ Cardiovasc Genet. 2015. PMID: 25691686 Free PMC article. Clinical Trial.
BACKGROUND: Genome-wide association studies have shown that the common single nucleotide polymorphism rs6800541 located in SCN10A, encoding the voltage-gated Nav1.8 sodium channel, is associated with PR-interval prolongation and atrial fibrillation (AF). Sing …
BACKGROUND: Genome-wide association studies have shown that the common single nucleotide polymorphism rs6800541 located in SCN10A, en …
Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction.
Man JCK, Bosada FM, Scholman KT, Offerhaus JA, Walsh R, van Duijvenboden K, van Eif VWW, Bezzina CR, Verkerk AO, Boukens BJ, Barnett P, Christoffels VM. Man JCK, et al. Circulation. 2021 Jul 20;144(3):229-242. doi: 10.1161/CIRCULATIONAHA.121.054083. Epub 2021 Apr 29. Circulation. 2021. PMID: 33910361
BACKGROUND: Genetic variants in SCN10A, encoding the neuronal voltage-gated sodium channel Na(V)1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac conduction velocities, and heart rate. ...CONCLUSIONS: Genetic variants in and aro …
BACKGROUND: Genetic variants in SCN10A, encoding the neuronal voltage-gated sodium channel Na(V)1.8, are strongly associated with …
Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation.
Delaney JT, Muhammad R, Shi Y, Schildcrout JS, Blair M, Short L, Roden DM, Darbar D. Delaney JT, et al. Europace. 2014 Apr;16(4):485-90. doi: 10.1093/europace/eut278. Epub 2013 Sep 26. Europace. 2014. PMID: 24072447 Free PMC article.
AIMS: SCN10A encodes the sodium channel Nav1.8 implicated by genome-wide association studies as a modulator of atrioventricular conduction (PR interval). In a cohort of patients with atrial fibrillation (AF), we examined whether there was an association betwe …
AIMS: SCN10A encodes the sodium channel Nav1.8 implicated by genome-wide association studies as a modulator of atrioventricular condu …
Molecular and Functional Relevance of Na(V)1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model.
Hartmann N, Knierim M, Maurer W, Dybkova N, Hasenfuß G, Sossalla S, Streckfuss-Bömeke K. Hartmann N, et al. Int J Mol Sci. 2023 Jun 15;24(12):10189. doi: 10.3390/ijms241210189. Int J Mol Sci. 2023. PMID: 37373335 Free PMC article.
In heart failure and atrial fibrillation, a persistent Na(+) current (I(NaL)) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. ...No effects on atrial APD(90) were detected in any groups. Both SCN10A KO and specific …
In heart failure and atrial fibrillation, a persistent Na(+) current (I(NaL)) exerts detrimental effects on cellular electroph …
Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-Lead Electrocardiograms.
Wang X, Khurshid S, Choi SH, Friedman S, Weng LC, Reeder C, Pirruccello JP, Singh P, Lau ES, Venn R, Diamant N, Di Achille P, Philippakis A, Anderson CD, Ho JE, Ellinor PT, Batra P, Lubitz SA. Wang X, et al. Circ Genom Precis Med. 2023 Aug;16(4):340-349. doi: 10.1161/CIRCGEN.122.003808. Epub 2023 Jun 6. Circ Genom Precis Med. 2023. PMID: 37278238 Free article.
BACKGROUND: Artificial intelligence (AI) models applied to 12-lead ECG waveforms can predict atrial fibrillation (AF), a heritable and morbid arrhythmia. However, the factors forming the basis of risk predictions from AI models are usually not well understood. ...RE …
BACKGROUND: Artificial intelligence (AI) models applied to 12-lead ECG waveforms can predict atrial fibrillation (AF), a herit …
SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.
Savio-Galimberti E, Weeke P, Muhammad R, Blair M, Ansari S, Short L, Atack TC, Kor K, Vanoye CG, Olesen MS, LuCamp, Yang T, George AL Jr, Roden DM, Darbar D. Savio-Galimberti E, et al. Cardiovasc Res. 2014 Nov 1;104(2):355-63. doi: 10.1093/cvr/cvu170. Epub 2014 Jul 22. Cardiovasc Res. 2014. PMID: 25053638 Free PMC article.
AIMS: To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare coding sequence variation in the SCN10A gene, which encodes the voltage-gated sodium channel isoform NaV1.8 found primarily in peripheral nerves and to identif …
AIMS: To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare coding sequence variation …
Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation.
Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H, Teumer A, Li-Gao R, Yao J, Guo X, Brody JA, Müller-Nurasyid M, Schramm K, Verweij N, van den Berg ME, van Setten J, Isaacs A, Ramírez J, Warren HR, Padmanabhan S, Kors JA, de Boer RA, van der Meer P, Sinner MF, Waldenberger M, Psaty BM, Taylor KD, Völker U, Kanters JK, Li M, Alonso A, Perez MV, Vaartjes I, Bots ML, Huang PL, Heckbert SR, Lin HJ, Kornej J, Munroe PB, van Duijn CM, Asselbergs FW, Stricker BH, van der Harst P, Kääb S, Peters A, Sotoodehnia N, Rotter JI, Mook-Kanamori DO, Dörr M, Felix SB, Linneberg A, Hansen T, Arking DE, Kooperberg C, Benjamin EJ, Lunetta KL, Ellinor PT, Lubitz SA. Weng LC, et al. Circ Genom Precis Med. 2020 Oct;13(5):387-395. doi: 10.1161/CIRCGEN.119.002874. Epub 2020 Aug 21. Circ Genom Precis Med. 2020. PMID: 32822252 Free PMC article.
BACKGROUND: The P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or prolonged PWD is associated with atrial fibrillation (AF). We used exome-chip data to examine the associations between common a …
BACKGROUND: The P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or p …
Association of Rare Genetic Variants and Early-Onset Atrial Fibrillation in Ethnic Minority Individuals.
Chalazan B, Mol D, Darbar FA, Ornelas-Loredo A, Al-Azzam B, Chen Y, Tofovic D, Sridhar A, Alzahrani Z, Ellinor P, Darbar D. Chalazan B, et al. JAMA Cardiol. 2021 Jul 1;6(7):811-819. doi: 10.1001/jamacardio.2021.0994. JAMA Cardiol. 2021. PMID: 33950154 Free PMC article.
IMPORTANCE: Although rare variants in cardiac ion channels, transcription factors, and myocardial structural proteins are associated with early-onset atrial fibrillation (AF) in White individuals of European descent, it remains unclear whether genetic variation also …
IMPORTANCE: Although rare variants in cardiac ion channels, transcription factors, and myocardial structural proteins are associated with ea …
Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue.
Sigurdsson MI, Saddic L, Heydarpour M, Chang TW, Shekar P, Aranki S, Couper GS, Shernan SK, Muehlschlegel JD, Body SC. Sigurdsson MI, et al. BMC Med Genomics. 2017 May 2;10(1):25. doi: 10.1186/s12920-017-0270-5. BMC Med Genomics. 2017. PMID: 28464817 Free PMC article. Clinical Trial.
BACKGROUND: Both ambulatory atrial fibrillation (AF) and post-operative AF (poAF) are associated with substantial morbidity and mortality. ...A previous relationship between rs3744029 and MYOZ1 expression was confirmed, and a novel relationship between rs6795970 and …
BACKGROUND: Both ambulatory atrial fibrillation (AF) and post-operative AF (poAF) are associated with substantial morbidity an …
Association of SCN10A Polymorphisms with the Recurrence of Atrial Fibrillation after Catheter Ablation in a Chinese Han Population.
Wu H, Xu J, Chen S, Zhou G, Qi B, Wei Y, Hu E, Tang D, Chen G, Li H, Zhao L, Shi Y, Liu S. Wu H, et al. Sci Rep. 2017 Mar 10;7:44003. doi: 10.1038/srep44003. Sci Rep. 2017. PMID: 28281580 Free PMC article.
The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. ...These data suggest that gen …
The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial …
34 results